natural sources of interferon alpha 2b

Granma had previously stated that Cuba was somehow developing 22 drugs to fight coronavirus, none of them accepted as treatments for the Wuhan virus. [8], Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), "Synthesis in E. coli of a polypeptide with human leukocyte interferon activity", "Cuban interferon alpha-2b. Interferon alfa-2b is an antiviral or antineoplastic drug. Interferon alfa-2b is an antiviral or antineoplastic drug. One study at the University of Texas Medical Branch, Galveston, showed evidence of a direct anti-viral effect of Interferon alpha against novel Coronavirus in vitro. Cuba has spent months promoting a domestically developed interferon – interferon-alpha 2b – as a successful antiviral against the Wuhan virus, offering little to no evidence. Interferon alfa-2b is a particular type of interferon protein that is already approved by the U.S. Food and Drug Administration (FDA) to treat certain viral infections and some forms of cancer when given directly through an IV. Cuba has documented 923 cases of Chinese coronavirus as of Friday; 31 people have died, according to the communist government. The gene IFN-α2b (interferon α 2b) is mapped to human chromosome 9. It does not have the minimum necessary to be considered a scientific investigation. Symptomatic and biochemical control may be obtained in 40% to 50% of patients with the recommended doses of 3 to 5 million units of recombinant interferon alfa-2a or interferon alfa-2b three to five times per week subcutaneously. The side effects are many,” Mena reportedly said. Human IFN-α2b is a 19.3kDa protein containing 165 amino acid residues. "Interferon: "It is a natural compound whose function is to create a mechanism of inhibition at the first level of the body's response" This medicine has been successfully used to treat outbreaks of dengue fever type 2 and hemorrhagic conjunctivitis in Latin America. They naturally exist in our system. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma. It belongs to the class of cytokines. 5: Type I interferon increase the expression of Class I MHC complex Interferon is a substance produced by the body's white cells to fight infections, cancer, allergies and toxic chemical poisoning. The human rights NGO Cuban Prisoners Defenders published an article on Friday citing three Cuban medical researchers who concluded that the communist regime’s publicity campaign for Interferon alpha-2b, which it claims can cure Chinese coronavirus, is a “serious crime against world public health.”. Interferon Alfa-2b (Professional Patient Advice) - Drugs.com Cuba manufactured its first interferon in 1981 and was used in the treatment of the haemorrhagic dengue epidemic in Cuba the same year. "Then a group of people went to Finland to get training in the production of interferon," while people were also producing Interferon from recombined sources using genetic engineering. Structurally, IFN-α2b is O-glycosylated at the threonine residue at position 106. “The side effects are like you’re in chemical therapy. [6] [7], This drug is also used off-label in cats and dogs, both by injection and orally. Interferon Alfa-2b Adult Medication. The model estimated that interferon-alpha 2b treatment in this population should increase life expectancy by 3.1 years if given at 20 years of age, by 1.5 years at 35 years of age, and by 22 days at 70 years of age; discounted marginal cost-effectiveness ratios are $500, $1900, and $62,000 per year of life gained, respectively. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. General description. How Interferon Alfa-2b Treats Cancer. Patients have nausea, vomiting, body pain, anemia; platelets, white blood cells are lowered … it is a very strong and difficult treatment. Countries from across the globe have asked Cuba for the Interferon Alpha 2B, a drug developed in Cuba proven to be an effective against COVID-19 A Cuban drug, known as the Interferon Alpha 2B, could save thousands of lives in the COVID-19 pandemic. Call your doctor at once if you have: unusual changes in mood or behavior, chest pain, trouble breathing, sudden numbness or weakness, or signs of infection (fever, chills, cough with mucus, or burning when you urinate). A cost-utility analysis using a model-based economic evaluation was conducted based on a societal perspective. Interferon is a substance produced by the body's white cells to fight infections, cancer, allergies and toxic chemical poisoning. HealthLatin AmericaNational SecurityChinacommunismcoronavirusCubainterferonsMedicineWorld Health OrganizationWuhan virus. Interferon alfa-2b can cause life-threatening infections, autoimmune disorders, serious mood or behavior problems, or a stroke. Granma, the official publication of the Cuban Communist Party, proclaimed in March that the Cuban interferon was showing “effectiveness in treating patients with the new SARS Cov-2 coronavirus.” It thanked Fidel Castro – a lawyer, not a virologist, by trade – for the “visionary thinking” that created the interferon and claimed that Cuban and Chinese scientists came up with the treatment together. A Markov model was developed to estimate costs and quality-adjusted life years (QALYs) comparing between the combination of pegylated interferon alpha 2a or alpha 2b and ribavirin with a usual palliative care for genotype 1 and 6 HCV patients. Objectives: Synthesize evidence of the natural history of chronic hepatitis B (CHB) and effects and harms of antiviral drugs on clinical, virological, histological, and biochemical outcomes. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon® Alfa R.[4], It has been used for a wide range of indications, including viral infections and cancers. The first one was Beta Interferon in Japan, and the second one was the family of Alpha Interferon by Genetec in California, according to the Cuban doctor. Interferon-alpha 2b’s use against coronavirus in Wuhan, where the virus originated, has become part of the Cuban state media lore about its success. The medication is being used in clinical trials to treat patients with SARS-CoV-2[5] although there are not yet published results of those trials on peer-reviewed scientific literature. As interferon-alpha has been used to treat hepatitis, the report quotes a hepatologist, Edward Mena, who states that their use results in a “very strong and difficult treatment.”. It can be made artificially and injected for some cancers and viral infections like HIV and hepatitis C, however there are side effects. Better efficacy of a 12-month interferon alfa-2b retreatment in patients with chronic hepatitis C relapsing after a 6-month treatment: a multicenter, controlled, randomized trial. Interferon drugs first emerged for cancer therapy. “Cuba generates from 2 to 6 times the national income of tourism through the “rent” in a state of slavery of doctors that are sent to more than 60 countries in the world,” the doctors write. Considered to be one of the greatest achievements of the Cuban biotechnology boom, this anti-viral drug called Interferon Alfa-2B is produced in China, by Cuban-Chinese joint venture ChangHeber.. One of the researchers the magazine quoted warned, “if it is given late in the disease it could easily lead to worse tissue damage instead of helping patients.”. The country later manufactured ‘recombinant’ human interferon Alfa-2B in 1986. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. Description. Once weekly dosing alfa 2b weight based dosing (1-1.5 mcg/kg/week) high volume of distribution kidney, heart, liver and throughout the bloodstream alfa 2a fixed dose at 180 mcg/week low volume of distribution The Wuhan coronavirus is believed to be closely related to the SARS coronavirus. Cuban Prisoners Defenders concludes that the “reckless and dangerous” use and promotion of the drug is an attempt by the Cuban government to enrich itself even further off of its medical businesses, the largest of which is its $11-billion-a-year slave doctor trade. Died, according to the communist government receive oxygen, and ultimately marketed by Schering-Plough under the name. Safe for you to take this drug is also used off-label in cats and dogs, both by and! Study demonstrated around 10,000 fold reduction in the treatment of the haemorrhagic dengue epidemic in cuba the same.... 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